钩藤碱

分析标准品,HPLC≥98%

Rhyncholphylline

CAS号：76-66-4

分子式：C22H28N2O4

分子量：384.47

MDL：MFCD00221748

产品介绍

熔点：216℃

沸点：560.8 ℃ at 760 mmHg

比旋光度：D13 -14.7° (c = 2.5 in chloroform)

外观：白色结晶

溶解性：溶于氯仿、丙tong、乙醇、苯，微溶于乙mi和醋酸乙酯，几乎不溶于石油醚。

储存条件：2-8℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(28篇)

28. [IF=6] Tao Hu et al."Haploid-Phased Chromosomal Telomere-to-Telomere Genome Assembly of Medicinal Plant Uncaria rhynchophylla Dissects Genetic Controls on the Biosynthesis of Bioactive Alkaloids."PLANT CELL AND ENVIRONMENT.2024 Nov;:

27. [IF=6.9] Lei Panpan et al."Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions."ARCHIVES OF PHARMACAL RESEARCH.2024 Dec;:1-13

26. [IF=6.8] Lin Lin et al."Rhynchophylline as an agonist of sirtuin 3 ameliorates endothelial dysfunction via antagonizing mitochondrial damage of endothelial progenitor cells."BRITISH JOURNAL OF PHARMACOLOGY.2025 Mar;:

25. [IF=1.3] Yongzhou Yu et al."Integrated UPLC-MS and multivariate data processing approach to explore the chemical components of Uncaria rhynchophylla and its absorbed components in rats following oral adminstration."JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNO

24. [IF=3.024] Xuan Yu et al."An innovative extraction strategy for herbal medicine by adopting p-sulphonatocalix[6]/[8]arenes."PHYTOCHEMICAL ANALYSIS

23. [IF=5.811] Liu  Jiao et al."Rhynchophylline Regulates Calcium Homeostasis by Antagonizing Ryanodine Receptor 2 Phosphorylation to Improve Diabetic Cardiomyopathy."Frontiers in Pharmacology. 2022 Apr;0:1375

22. [IF=6.529] Lingling Xie et al."Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway."Biomed Pharmacother. 2022 Feb;146:112607

21. [IF=2.649] Long Hongyan et al."Rhynchophyllin attenuates neuroinflammation in Tourette syndrome rats via JAK2/STAT3 and NF‐κB pathways."Environ Toxicol. 2019 Oct;34(10):1114-1120

20. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

19. [IF=3.935] Wenwen Huang et al."Rapid discovery of potentially vasodilative compounds from Uncaria by UHPLC/Q-Orbitrap-MS based metabolomics and correlation analysis."J Pharmaceut Biomed. 2021 Nov;206:114384

18. [IF=3.996] Jiang  Pan et al."Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation."Neurochem Res. 2021 Sep;46(9):2439-2450

17. [IF=4.759] Keyu Feng et al."Configuration of the ion exchange chromatography, hydrophilic interaction chromatography, and reversed-phase chromatography as off-line three-dimensional chromatography coupled with high-resolution quadrupole-Orbitrap mass spectrometry fo

16. [IF=1.908] Xin  Wang et al."Stereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography–tandem mass spectrometry."Xenobiotica. 2017;47(6):479-487

15. [IF=3.935] Shuanglu Xie et al."Systematic identification and quantification of tetracyclic monoterpenoid oxindole alkaloids in Uncaria rhynchophylla and their fragmentations in Q-TOF-MS spectra."J Pharmaceut Biomed. 2013 Jul;81-82:56

14.  邓向涛,张文周,张智强.钩藤碱纳米混悬剂缓释片制备、优化与体外释放评价[J].中草药,2020,51(20):5128-5136.

13.  范素芳, 马俊美, 刘茁,等. 高效液相色谱-串联质谱测定食品中15种有毒生物碱[J]. 食品科学, 2018, 39(22):290-295.

12.  郭晓敏, 黄宝媛, 曾常青. 钩藤生物碱提取物及其单体逆转HepG2/ADM细胞耐药活性的筛选[J]. 广东药学院学报, 2018, 034(004):447-451.

11.  樊晖, 田原. 正交试验优选天麻安神颗粒乙醇提取工艺[J]. 中国实验方剂学杂志, 2015, 21(7):21-23.

10.  刘明, 王慧森, 李更生. 春花降压片的质量标准研究[J]. 西北药学杂志, 2020, v.35(03):9-12.

9.  张媛媛  曾慧婷  陈超 等. 以离子液体为流动相添加剂的HPLC法分离并测定钩藤中钩藤碱和异钩藤碱的含量[J]. 中国药房  2019  v.30;No.663(21):77-82.

8.  龙国友  王美  孙刚. HPLC法测定安乐片中钩藤碱和异钩藤碱的含量[J]. 中国药品标准  2017(4).

7.  李素珍, 唐振祥, 吴卫. 钩藤碱脂质体的制备及释放度研究[J]. 中华中医药杂志, 2013, 028(012):3730-3732.

6.  赵兴业, 王颖慧, 崔晓鸽,等. 钩藤碱双层渗透泵控释片的制备及处方优化[J]. 中成药, 2020, v.42(05):17-21.

5.  徐有伟, 黄真, 周洪雷,等. 藤菔降压片质量控制研究[J]. 中药新药与临床药理, 2015, 026(005):690-694.

4.  黄真, 周洪雷, 李运伦,等. 藤菔降压片指纹图谱评价体系研究[J]. 辽宁中医杂志, 2014, 041(006):1251-1253.

3.  闫瑞, 李凌军, 李顺. 天钩降压胶囊中钩藤碱大鼠体内药动学研究[J]. 山东中医药大学学报, 2014, 000(003):257-259.

2.  李季, 李凌军, 娄华伟. 天钩降压胶囊中钩藤碱、异钩藤碱大鼠在体肠吸收动力学研究[J]. 中国实验方剂学杂志, 2013, 19(6):167-170.

1.  娄华伟, 李凌军, 李季. 天钩降压胶囊中钩藤碱、异钩藤碱在大鼠离体小肠的吸收动力学研究[J]. 中国实验方剂学杂志, 2013, 19(7):150-153.