大黄酚

分析标准品,HPLC≥98%

Chrysophanol

CAS号：481-74-3

分子式：C15H10O4

分子量：254.24

MDL：MFCD00001208

产品介绍

熔点：194-198℃

沸点：489.5℃at760mmHg

外观：金黄色结晶

溶解性：几乎不溶于水,  DMSO：1mg/ml。

储存条件：2-8℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(55篇)

55. [IF=4.8] Xuan Gou et al."Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury."Frontiers in Pharmacology.2025 Jul;16:

54. [IF=4.4] Chenxi Wang et al."Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers."Fronti

53. [IF=4.8] Feng-lin Zhang et al."Huashi baidu granule alleviates inflammation and lung edema by suppressing the NLRP3/caspase-1/GSDMD-N pathway and promoting fluid clearance in a porcine reproductive and respiratory syndrome (PRRS) model."JOURNAL OF ETHNOPHARMACOLOG

52. [IF=7.1] Jiahui Gong et al."Smart Dual-Responsive Ionic Liquid as Transformable and Recyclable Media for Extracting and Separating Phytochemicals from Wild Rumex acetosa L.."ACS Sustainable Chemistry & Engineering.2024;XXXX(XXX):XXX-XXX

51. [IF=6.7] Kaixin Liu et al."Polydatin mitigates thrombosis by inhibiting PHD2-induced proline hydroxylation on collagen, reducing platelet adhesion."PHYTOMEDICINE.2025 Mar;138:156392

50. [IF=5.7] Lili Yang et al."Herbal HuoXueTongFu Formula with anti-inflammatory and fibrinolytic activity regulation for the prevention of postoperative peritoneal adhesions."Frontiers in Immunology.2025 Jan;15:

49. [IF=6.1] Jia Guo et al."Discovery of anthraquinones as potent Notum inhibitors for treating osteoporosis by integrating biochemical, phytochemical, computational, and experimental assays."Journal of Pharmaceutical Analysis.2025 Mar;:101256

48. [IF=4.8] Chunying Li et al."A green and sustainable synthesis of polydopamine molecularly imprinted resin for selective recognition emodin in Rumex acetosa L.: experiments and simulation."Food Bioscience.2025 Apr;:106674

47. [IF=1.4] Sunghanghwa Yuwathida et al."Plasmodium falciparum Lactate Dehydrogenase Inhibitory Activities of Pomegranate and Mangosteen Extracts and their Major Constituents."Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy.2024 Jul;:1-10

46. [IF=5.3] Chuanxi Tian et al."Exploring the therapeutic efficacy: Unveiling the active compounds of Huashi Baidu granules against COVID-19."Arabian Journal of Chemistry.2024 Sep;17:105910

45. [IF=4.1] Xiaoyao Liu et al."The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways."Metabolites".2024 Apr;14(4):216

44. [IF=2] Lin Zhou et al."Therapeutic Potential of Danyankang Capsule in High-Fat Diet-Induced Cholelithiasis and Its Impact on Liver FXR Signaling and Gut Microbiota."BIOLOGICAL & PHARMACEUTICAL BULLETIN".2024 Mar;47(3):680-691

43. [IF=2.5] Wei Huang et al."Neuroprotective effect of chrysophanol in Alzheimer disease via modulating the Ca2+/EGFR-PLCγ pathway."NEUROSCIENCE LETTERS".2024 Feb;824:137684

42. [IF=4.9] Zhao Xia et al."Comparative transcriptome analysis and identification of candidate R2R3-MYB genes involved in anthraquinone biosynthesis in Rheum palmatum L.."Chinese Medicine".2024 Dec;19(1):1-18

41. [IF=3.6] Zhang Xiao-yan et al."Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease."METABOLIC BRAIN DISEASE.2023 Nov;:1-11

40. [IF=3.4] Si Li et al."Active ingredients of Erhuang Quzhi Granules for treating non-alcoholic fatty liver disease based on the NF-κB/NLRP3 pathway."FITOTERAPIA.2023 Dec;171:105704

39. [IF=2.8] Luo Jing et al."Chrysophanol improves memory impairment and cell injury by reducing the level of ferroptosis in Aβ25–35 treated rat and PC12 cells."3 Biotech.10.1007/s13205-023-03769-8

38. [IF=4.5] Guangtao Pan et al."Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways."Journal of Traditional and Complementary Medicine.10.1016/j.jtcme.2023.09.001

37. [IF=4.9] Zhang Min et al."Discovery and evaluation of active compounds from Xuanfei Baidu formula against COVID-19 via SARS-CoV-2 Mpro."Chinese Medicine.2023 Dec;18(1):1-14

36. [IF=3.1] Cuicui Liu et al."Identification and quantitative analysis of the chemical constituents of Gandouling tablets using ultra-high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry."JOURNAL OF SEPARATION SCIENCE.2023 Jun;:2300

35. [IF=3.8] Yongle Yu et al."Novel anthraquinone photosensitizers: Synthesis, photoactivity, and 3D-QSAR studies."JOURNAL OF MOLECULAR STRUCTURE.2023 Nov;1292:136107

34. [IF=5.093] Zhang Meng et al."Chrysophanol exerts a protective effect against Aβ25-35-induced Alzheimer’s disease model through regulating the ROS/TXNIP/NLRP3 pathway."INFLAMMOPHARMACOLOGY.2023 Mar;:1-17

33. [IF=3.577] Liqing Zheng et al."The oxidative stress, mitochondrial pathway apoptosis, and the antagonistic effects of chrysophanol in SH-SY5Y cells via DTPP-induced photodynamic therapy."Photodiagnosis and Photodynamic Therapy.2022 Aug;:103062

32. [IF=3.205] Jiayun Chen et al."HRPIF data mining based on data-dependent/independent acquisition for Rhei Radix et Rhizoma metabolite screening in rats."J Chromatogr B. 2022 Feb;1190:123095

31. [IF=6.165] Yaofen Li et al.Study on the effects of deep eutectic solvents as a reaction media on the micromorphology of hydrogen-substituted graphyne and its adsorption and electrochemical properties.J Mol Liq. 2021 Nov;:118177

30. [IF=0.986] Ji-le Lan et al."Q-marker Prediction Analysis of Rhubarb in Fengyin Decoction Based on Fingerprint and Network Pharmacology:."Nat Prod Commun. 2021;16(8):

29. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

28. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328

27. [IF=3.935] Li Xie et al."Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms."J Pharmaceut Biomed. 2019 Sep;174:696

26. [IF=4.36] Li Lin et al."Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism."J Ethnopharmacol. 2020 Apr;252:112577

25. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra

24. [IF=5.645] Li-Xia Dai et al."Ultrasound-assisted extraction of five anthraquinones from Rheum palmatum water extract residues and the antimicrobial activities."Ind Crop Prod. 2021 Apr;162:113288

23. [IF=5.81] Zhihui Yin et al."Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis."Front Pharmacol. 2021; 12: 746711

22. [IF=2.406] Guo  Lei et al."Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic Vibrio harveyi."3 Biotech. 2017 Dec;7(6):1-9

21. [IF=3.366] Wu  Xingqiang et al."A Novel Selective Accelerated Solvent Extraction for Effective Separation and Rapid Simultaneous Determination of Six Anthraquinones in Tartary Buckwheat and Its Products by UPLC–DAD."Food Anal Method. 2015 May;8(5):1124-1132

20.  Xie, Li, et al. "Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms." Journal of pharmaceutical and biomedical analysis 174 (2019):

19.  Guo, L., Guo, J. & Xu, F. Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic Vibrio harveyi . 3 Biotech 7, 377 (2017). https:##doi.org/10.1007/s13205-017-1012-2

18.  张明明. 大黄道地产区核心种质构建及优良种质筛选研究[D].北京中医药大学,2020.

17.  李承浩,王萌,任晓亮.磺化杯6芳烃对4类中药单体成分增溶作用及其机制研究[J].中国现代中药,2020,22(12):2032-2038.

16.  兰济乐,阮叶萍,邱璐琦.基于BAS-GA-BP神经网络结合熵权法多指标优化风引汤提取工艺[J].中国中药杂志,2020,45(23):5686-5693.

15.  青,何前松,胡斐然,蔡友德,李宇鸿.大黄酚通过TLR4/NF-kB信号通路途径调控小胶质细胞炎性反应[J].医学信息,2020,33(19):51-54+58.

14.  陆杰,王婷婷,梁琨,安叡,王新宏,陈颖.UPLC-LTQ-Orbitrap-MS法分析大承气汤化学成分[J].中成药,2020,42(12):3275-3280.

13.  张亚洲,蔡友德,胡斐然,郭青,李宇鸿,何前松.大黄酚对脑缺血损伤模型大鼠小胶质细胞活化及炎症因子表达的影响[J].中国药房,2020,31(23):2858-2863.

12.  刘全德,唐仕荣,宋慧,王营,邢洪伟.芦荟蒽醌类化合物的超声提取及其抗氧化性研究[J].食品与机械,2011,27(05):68-71.

11.  郭允, 陈永超, 李晓花,等. 牛黄解毒片中6种指标成分的含量测定[J]. 沈阳药科大学学报, 2016(6):454-458.

10.  陈侃, 王长谦, 范虞琪,等. 斑马鱼平台研究七种中药单体的降脂作用[J]. 生理学报, 2017, 069(001):55-60.

9.  杨强  蒲晓辉  李晓花. 一清胶囊中7种指标成分的测定[J]. 华西药学杂志  2017(3).

8.  李晓花 郭允 李佳 袁琦 蒲晓辉 王高峰.RP-HPLC法同时测定三黄片中7种指标成分的含量[J].沈阳药科大学学报 2016 33(08):637-642.

7.  魏艳婷  张静宜  张华潭 等. HPLC法同时测定三黄滴丸中5种蒽醌类成分的含量[J]. 中国药房  2015.

6.  黑小斌,李欢,李依民,王光辉,徐进,彭亮,邓翀,颜永刚,郭顺星,张岗.药用大黄幼苗转录组高通量测序及蒽醌类生物合成基因筛选[J].中国药学杂志,2019,54(07):526-535.

5.  李红英  向极钎  龙澜 等. HPLC法测定大黄药材中5种游离蒽醌的含量[J]. 安徽农业科学  2013(12):5278-5279.

4.  李欢  黑小斌  李依民 等. HPLC法分析不同年限及不同部位掌叶大黄9种成分的积累特征[J]. 天然产物研究与开发  2019  031(006):923-931.

3.  李欢  黑小斌  李依民 等. HPLC分析不同年限药用大黄不同部位中10种成分的积累特征[J]. 中草药  2019  50(07):191-198.

2.  杨国静  张珞琪  陈随清 等. 不同商品规格决明子的质量分析[J]. 中国现代中药  2018  v.20(08):963-967.

1.  贾丽华 黄刚 王东东 付晓.HPLC法测定不同厂家三黄片中大黄素与大黄酚的含量[J].兵团医学 2016 47(01):51-53.

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